blood-brain barrier

noun

: a naturally occurring barrier created by the modification of brain capillaries (as by reduction in fenestration and formation of tight cell-to-cell contacts) that prevents many substances from leaving the blood and crossing the capillary walls into the brain tissues

Examples of blood-brain barrier in a Sentence

Recent Examples on the Web
Examples are automatically compiled from online sources to show current usage. Read More Opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback.
However, the team found endocannabinoid receptors in and around the blood-brain barrier. William A. Haseltine, Forbes, 25 Mar. 2025 But our brains are designed to keep things out, through something called the blood-brain barrier. Megha Satyanarayana, Scientific American, 14 Feb. 2025 Creatine crosses the blood-brain barrier, and neurons can make it within the central nervous system.11 Brain creatine levels may decrease during stressful conditions. Melissa Nieves, Verywell Health, 13 Mar. 2025 This occurs when cancer cells migrate through the blood-brain barrier. Charna Flam, People.com, 7 Mar. 2025 See All Example Sentences for blood-brain barrier

Word History

First Known Use

1934, in the meaning defined above

Time Traveler
The first known use of blood-brain barrier was in 1934

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Cite this Entry

“Blood-brain barrier.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/blood-brain%20barrier. Accessed 16 Apr. 2025.

Medical Definition

blood-brain barrier

noun
: a naturally occurring barrier created by the modification of brain capillaries (as by reduction in fenestration and formation of tight cell-to-cell contacts) that prevents many substances from leaving the blood and crossing the capillary walls into the brain tissues
abbreviation BBB

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