break·through
ˈbrāk-ˌthrü 
plural breakthroughs
1
a
: a sudden advance especially in knowledge or technique
a medical breakthrough
b
: a person's first notable success
—often used before another noun
a breakthrough novel
the actress's breakthrough performance
2
a
: an act or instance of moving through or beyond an obstacle
a breakthrough in the talks between the region's leaders
a breakthrough agreement
b
: an instance of passing through a barrier or protection
The ice under the surface begins to deteriorate, increasing the risk of breakthroughs.—
Vicki Winger
Vicki Winger
specifically, medical
: infection occurring in someone who is fully vaccinated against an infectious agent
A vaccine breakthrough occurs when a person tests positive for COVID-19 two weeks after being fully vaccinated against the disease … —David Rasbach
—often used before another noun David Rasbach Two other CDC studies of breakthrough cases at nursing homes showed the vaccines protected residents, even when the virus spread through the homes. —Maura Dolan
Maura Dolan … the academy recently recommended that children receive two doses of the chicken pox vaccine, rather than just one, because the additional dose bolsters immunity and may help reduce breakthrough infection. —Maria Raven
Maria Raven 3
warfare
: an offensive military assault that penetrates and carries beyond a defensive line
broke through; broken through; breaking through; breaks through
: to make a breakthrough
Examples of breakthrough in a Sentence
Noun
Researchers say they have made a major breakthrough in cancer treatment.
The police have announced a breakthrough in the murder case.
This job could be the breakthrough she's been waiting for.
Recent Examples on the Web
Julia Emmanuele, People.com, 19 July 2025
Clueless was Murphy's breakthrough film, kicking off an impressive but tragically short career.
—Danny Horn, EW.com, 19 July 2025
Arkansas Online, 19 July 2025
The cushy lifestyle broke through in viral videos last year, with residents showing off the camps, to the chagrin of management.
—Matthew Martin, semafor.com, 18 July 2025
See All Example Sentences for breakthrough
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Noun
After her breakthrough role as the bubbly, naïve Tai, Brittany Murphy's film career took off, landing her starring roles in 8 Mile (2002), Uptown Girls (2003), Just Married (2003) and Sin City (2005).
—Julia Emmanuele, People.com, 19 July 2025
Clueless was Murphy's breakthrough film, kicking off an impressive but tragically short career.
—Danny Horn, EW.com, 19 July 2025
Verb
Mogollon, 25, and three other men had busted out of the Delaney Hall detention center in Newark by breaking through a wall and escaping from a parking lot, according to U.S. Sen. Andy Kim, D-N.J., and Homeland Security officials.
—Arkansas Online, 19 July 2025
The cushy lifestyle broke through in viral videos last year, with residents showing off the camps, to the chagrin of management.
—Matthew Martin, semafor.com, 18 July 2025
See All Example Sentences for breakthrough
Cite this Entry
“Breakthrough.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/breakthrough. Accessed 22 Jul. 2025.
Copy CitationKids Definition
breakthrough
noun
break·through
ˈbrāk-ˌthrü
: a sudden advance in knowledge or technique
a breakthrough in medical science
Medical Definition
breakthrough
noun
break·through
ˈbrāk-ˌthrü
: infection occurring in someone who is fully vaccinated against an infectious agent
—often used before another noun
breakthrough infections
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