cortisol

noun

cor·​ti·​sol ˈkȯr-tə-ˌsȯl How to pronounce cortisol (audio)
-ˌzȯl,
-ˌsōl,
-ˌzōl
: a glucocorticoid C21H30O5 produced by the adrenal cortex upon stimulation by ACTH that mediates various metabolic processes (such as gluconeogenesis), has anti-inflammatory and immunosuppressive properties, and whose levels in the blood may become elevated in response to physical or psychological stress

called also hydrocortisone

Examples of cortisol in a Sentence

Recent Examples on the Web
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That means more time to focus on important things, like regulating your cortisol levels or hunting down the perfect beach outfit. Iman Balagam, Vogue, 17 July 2025 High-pressure situations, like competitions, can put the body into states of hyperarousal, where the body is surging with cortisol, adrenaline, and dopamine. Brook Choulet, Forbes.com, 16 July 2025 Engineers developed dental floss that tests cortisol levels. Rafil Kroll-Zaidi, Harpers Magazine, 16 July 2025 Certain supplements and lifestyle changes may help keep cortisol levels in check.1 1. Cristina Mutchler, Verywell Health, 15 July 2025 See All Example Sentences for cortisol

Word History

Etymology

cortisone + -ol entry 1

First Known Use

1951, in the meaning defined above

Time Traveler
The first known use of cortisol was in 1951

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Cite this Entry

“Cortisol.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/cortisol. Accessed 22 Jul. 2025.

Medical Definition

cortisol

noun
: a glucocorticoid C21H30O5 produced by the adrenal cortex upon stimulation by ACTH that mediates various metabolic processes (as gluconeogenesis), has anti-inflammatory and immunosuppressive properties, and whose levels in the blood may become elevated in response to physical or psychological stress

called also hydrocortisone

More from Merriam-Webster on cortisol

Last Updated: - Updated example sentences
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