diphenhydramine
noun
di·phen·hy·dra·mine
ˌdī-ˌfen-ˈhī-drə-ˌmēn 
: an antihistamine C17H21NO used especially in the form of its hydrochloride
Examples of diphenhydramine in a Sentence
Recent Examples on the Web
Anticholinergics are used to reduce cold and flu symptoms (diphenhydramine/Benadryl), relieve motion sickness and histamine reactions (promethazine/Phenergan) and relax the bladder to limit frequent urination (oxybutynin/Ditropan).
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New Atlas, 11 July 2025
Kratom and diphenhydramine, however, had a severe interaction that led to his death.
—Nick Coltrain, Denver Post, 23 May 2025
Carefully review and follow medication labels to avoid giving more than one product containing diphenhydramine at the same time.
—T'keyah Bazin, Verywell Health, 30 May 2025
Ask your provider about taking an antihistamine, such as Benadryl (diphenhydramine), to help with swelling or itching.
—Carrie Madormo, Verywell Health, 5 June 2025
See All Example Sentences for diphenhydramine
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New Atlas, 11 July 2025
Kratom and diphenhydramine, however, had a severe interaction that led to his death.
—Nick Coltrain, Denver Post, 23 May 2025
Carefully review and follow medication labels to avoid giving more than one product containing diphenhydramine at the same time.
—T'keyah Bazin, Verywell Health, 30 May 2025
Ask your provider about taking an antihistamine, such as Benadryl (diphenhydramine), to help with swelling or itching.
—Carrie Madormo, Verywell Health, 5 June 2025
See All Example Sentences for diphenhydramine
Cite this Entry
“Diphenhydramine.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/diphenhydramine. Accessed 20 Jul. 2025.
Copy CitationMedical Definition
diphenhydramine
noun
di·phen·hy·dra·mine
ˌdī-ˌfen-ˈhī-drə-ˌmēn
: an antihistamine used especially in the form of its hydrochloride C17H21NO·HCl to treat allergy symptoms and motion sickness and to induce sleep see benadryl
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