diphenhydramine

noun

di·​phen·​hy·​dra·​mine ˌdī-ˌfen-ˈhī-drə-ˌmēn How to pronounce diphenhydramine (audio)
: an antihistamine C17H21NO used especially in the form of its hydrochloride

Examples of diphenhydramine in a Sentence

Recent Examples on the Web
Examples are automatically compiled from online sources to show current usage. Read More Opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback.
Ask your provider about taking an antihistamine, such as Benadryl (diphenhydramine), to help with swelling or itching. Carrie Madormo, Verywell Health, 5 June 2025 Antihistamines: Oral antihistamines like Benadryl (diphenhydramine) can be effective if your itch is due to an allergic reaction. Sarah Jividen, Health, 22 May 2025 While on trial, defense lawyer Megan Kau argued that others, including Anna or Abigail’s father, could have given diphenhydramine to the infant. Becca Longmire, People.com, 12 May 2025 Antihistamines: These medications, such as Benadryl (diphenhydramine), can relieve mild food allergies. Wendy Wisner, Health, 18 Apr. 2025 See All Example Sentences for diphenhydramine

Word History

First Known Use

1948, in the meaning defined above

Time Traveler
The first known use of diphenhydramine was in 1948

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Cite this Entry

“Diphenhydramine.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/diphenhydramine. Accessed 8 Jun. 2025.

Medical Definition

diphenhydramine

noun
di·​phen·​hy·​dra·​mine ˌdī-ˌfen-ˈhī-drə-ˌmēn How to pronounce diphenhydramine (audio)
: an antihistamine used especially in the form of its hydrochloride C17H21NO·HCl to treat allergy symptoms and motion sickness and to induce sleep see benadryl

More from Merriam-Webster on diphenhydramine

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