: being the preferred, standard, or first choice
first-line treatment of tuberculosis
compare second-line

Examples of first-line in a Sentence

surgery is usually not considered a first-line treatment for this type of cancer
Recent Examples on the Web
Examples are automatically compiled from online sources to show current usage. Read More Opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback.
While medications are often the first-line treatment for LBP, non-pharmaceutical treatments, such as physical therapy, can help. New Atlas, 6 Apr. 2025 Though some were once commonly prescribed, they are not recommended as first-line treatments for many people for various reasons. Karen Berger, Pharmd, Verywell Health, 28 Mar. 2025 The nine games remaining will be a good opportunity for Mittelstadt to make his case to be Pastrnak’s first-line center in 2025-26. Fluto Shinzawa, New York Times, 28 Mar. 2025 These results support continued use of oseltamivir as the first-line treatment and for post-exposure prophylaxis in close contacts of infected individuals. John Drake, Forbes.com, 27 Mar. 2025 See All Example Sentences for first-line

Word History

First Known Use

1919, in the meaning defined above

Time Traveler
The first known use of first-line was in 1919

Browse Nearby Words

Cite this Entry

“First-line.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/first-line. Accessed 16 Apr. 2025.

Medical Definition

first-line

adjective
: being the preferred, standard, or first choice
first-line treatment of advanced breast cancer
compare second-line
Last Updated: - Updated example sentences
Love words? Need even more definitions?

Subscribe to America's largest dictionary and get thousands more definitions and advanced search—ad free!