1
: of superior grade or quality
high-grade bonds
2
a
: being near the upper or most favorable extreme of a specified range
b
: medically serious or life-threatening
a high-grade tumor

Examples of high-grade in a Sentence

Recent Examples on the Web
Examples are automatically compiled from online sources to show current usage. Read More Opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback.
Follow up with the Silky Soft Plumping Cream, a next-generation moisturiser powered by copper tripeptide (to help reduce wrinkles), Japanese Ume extract (to help boost collagen), and Argireline (a high-grade peptide). Angelina Villa-Clarke, Forbes.com, 21 July 2025 The issue was brought to his attention by reporting from The Bee and other news outlets highlighting a stark difference between state and federal law concerning who can be licensed to work with high-grade explosives like those that sparked an inferno in Esparto on July 1. Daniel Lempres, Sacbee.com, 17 July 2025 Before Schmidt’s injury, the Yankees lost ace Gerrit Cole to season-ending elbow surgery, while Luis Gil has been out since spring training due to a high-grade lat strain. Peter Sblendorio, New York Daily News, 9 July 2025 Patients with the condition undergo endoscopies to look for dysplasia, which can be low-grade or high-grade. Jack Knudson, Discover Magazine, 24 June 2025 See All Example Sentences for high-grade

Word History

First Known Use

1826, in the meaning defined at sense 1

Time Traveler
The first known use of high-grade was in 1826

Cite this Entry

“High-grade.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/high-grade. Accessed 25 Jul. 2025.

Kids Definition

high-grade

adjective
ˈhī-ˈgrād
: of a better grade or quality

Medical Definition

high-grade

adjective
: being near the upper, most serious, or most life-threatening extreme of a specified range
high-grade gliomas
high-grade cervical dysplasia
compare low-grade

More from Merriam-Webster on high-grade

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