naloxone

noun

nal·​ox·​one na-ˈläk-ˌsōn How to pronounce naloxone (audio)
: a synthetic potent antagonist of narcotic drugs (such as morphine and fentanyl) that is administered especially in the form of its hydrochloride C19H21NO4·HCl

Note: Naloxone is administered by injection or as a nasal spray to reverse the effects of opioids especially in the emergency treatment of opioid overdose. It is also administered in combination with buprenorphine in the form of a dissolvable tablet placed under the tongue or a film placed inside the cheek to treat opioid dependence.

Examples of naloxone in a Sentence

Recent Examples on the Web
Examples are automatically compiled from online sources to show current usage. Read More Opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback.
Experts attribute the decrease to several factors, including broader access to the opioid antidote naloxone, $50 billion in funding for drug treatment and youth prevention from national opioid settlements, and a crackdown on drugs smuggled through Canada and Mexico. Rebecca Morin, USA Today, 15 May 2025 Some reasons given were an increase in the availability of overdose-reversing drug naloxone, expanded addiction treatment, and changes in the way people use drugs. Dan Gooding, MSNBC Newsweek, 14 May 2025 Some organizations may be eligible for free naloxone through the Department of Health Care Services’ Naloxone Distribution Project. Caelyn Pender, Mercury News, 23 Apr. 2025 The sergeant gave the teen naloxone before she was taken to the hospital. Abigail Hasebroock, Sun Sentinel, 26 Feb. 2025 See All Example Sentences for naloxone

Word History

Etymology

N-allyl + hydroxy- + -one

First Known Use

1964, in the meaning defined above

Time Traveler
The first known use of naloxone was in 1964

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Cite this Entry

“Naloxone.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/naloxone. Accessed 4 Jun. 2025.

Medical Definition

naloxone

noun
: a potent synthetic antagonist of narcotic drugs (as morphine and fentanyl) that is administered especially in the form of its hydrochloride C19H21NO4·HCl

Note: Naloxone is administered by injection or as a nasal spray to reverse the effects of opioids and especially in the emergency treatment of opioid overdose. It is also administered in combination with buprenorphine in the form of a dissolvable tablet placed under the tongue or a film placed inside the cheek to treat opioid dependence. Trademarks for preparations containing naloxone include Bunavail, Evzio, Narcan, Suboxone, and Zubsolv.

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