serotonin

noun

se·​ro·​to·​nin ˌsir-ə-ˈtō-nən How to pronounce serotonin (audio)
ˌser-
: a phenolic amine neurotransmitter C10H12N2O that is a powerful vasoconstrictor and is found especially in the brain, blood serum, and gastric mucous membrane of mammals

Examples of serotonin in a Sentence

Recent Examples on the Web
Examples are automatically compiled from online sources to show current usage. Read More Opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback.
Although the exact link between B6 and anxiety is unclear, research suggests that vitamin B6 relieves anxiety and fear by regulating the production of serotonin and gamma-aminobutyric acid (GABA). Emmanuella Ogbonna, Health, 19 May 2025 Moving our bodies releases serotonin and endorphins and improves our hippocampus function. Jessica Dulong, CNN Money, 12 May 2025 TCAs, like amitriptyline (Elavil), are primarily used to treat depression but also work by increasing the levels of certain neurotransmitters like serotonin and norepinephrine in the brain and spinal cord. New Atlas, 22 Apr. 2025 Time in nature An indoor, sedentary lifestyle does not increase endorphins and serotonin. Ana Morales, Vogue, 7 Apr. 2025 See All Example Sentences for serotonin

Word History

Etymology

sero- + ton(ic) entry 2 or tone entry 1 + -in entry 1, probably after angiotonin, earlier name for angiotensin — more at angiotensin

Note: Term introduced by Maurice M. Rapport, Arda Alden Green and Irvine H. Page in "Crystalline serotonin," Science, vol. 108, Issue 2804 (September 24, 1948), pp. 329-330: "The general behavior of the crystalline substance is suggestive of its homogeneity. We would like provisionally to name it serotonin, which indicates that its source is serum and its activity is one of causing constriction."

First Known Use

1948, in the meaning defined above

Time Traveler
The first known use of serotonin was in 1948

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Cite this Entry

“Serotonin.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/serotonin. Accessed 7 Jun. 2025.

Medical Definition

serotonin

noun
se·​ro·​to·​nin ˌsir-ə-ˈtō-nən How to pronounce serotonin (audio) ˌser- How to pronounce serotonin (audio)
: a phenolic amine neurotransmitter C10H12N2O that is a powerful vasoconstrictor and is found especially in the brain, blood serum, and gastric mucous membrane of mammals

called also 5-HT, 5-hydroxytryptamine

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