prefrontal cortex

noun

: the gray matter of the anterior part of the frontal lobe that is highly developed in humans and plays a role in the regulation of complex cognitive, emotional, and behavioral functioning

Examples of prefrontal cortex in a Sentence

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These hormones act on specific regions of the brain, including the hypothalamus and prefrontal cortex. William A. Haseltine, Forbes.com, 18 July 2025 That universality, coupled with the sense that before the prefrontal cortex has fully formed, feelings will always run hot and bright, meant that the writers had a lot of empathy for these characters. Laura Zornosa, Los Angeles Times, 15 May 2025 Ninety percent of brain development happens before the age of 6, with the prefrontal cortex being the last part of that development. Hannah Nwoko, Parents, 1 May 2025 In the new study, published in Nature, researchers analyzed over two million cell nuclei from the brain tissue of 111 people, focusing on a region called the dorsolateral prefrontal cortex, which is linked to decision-making and emotional control. Pranjal Malewar, New Atlas, 6 July 2025 See All Example Sentences for prefrontal cortex

Word History

First Known Use

1892, in the meaning defined above

Time Traveler
The first known use of prefrontal cortex was in 1892

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Cite this Entry

“Prefrontal cortex.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/prefrontal%20cortex. Accessed 23 Jul. 2025.

Medical Definition

prefrontal cortex

noun
: the gray matter of the anterior part of the frontal lobe that is highly developed in humans and plays a role in the regulation of complex cognitive, emotional, and behavioral functioning
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